ABSTRACT
Objective To optimize the best prescription of Yuanhu Zhitong Oral Disintegrating Tablets (YZODT). Methods Using the single factor test, the prescription of the tablets was optimized by central composite design-response surface methodology (CCD-RSM) with the tablet wetting time and the disintegration time limit as evaluation index, so as to determine the best preparation process. Results The dosages of the optimized prescription of MCC, L-HPC, and PVPP were 30%, 15%, and 5%, respectively. The average disintegration time of the optimized YZODT was 42.89 s, and the deviation from the predicted value was 3.27%. Conclusion The optimized YZODT has the advantages of fast disintegration, moderate hardness, convenient use, and simple process.
ABSTRACT
Spray with its unique form of administration, greatly facilitates the patients in the oral cavity, skin, and mucous membrane of the drug delivery. And it has been widely used in the treatment of local and systemic diseases in clinical application. Chinese materia medica (CMM) spray combined with traditional medicine and modern preparation technology and technique has developed rapidly in recent years. The number of researches and development products of Chinese materia medica spray is numerous, but on the whole, the technical level of the products is low and many problems exist in the prescription design, quality control, etc. By consulting the relevant literature of recent years, this paper reviewed the current situation of product development, preparation technology, and quality control of CMM spray, in order to provide new ideas for the research of spray, and to provide a reference for the better development of CMM spray products.